解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS/HYPOTHESIS:The study aimed to investigate whether baseline physical activity protects against the occurrence of type 2 diabetes during a 28 year follow-up, after controlling for childhood environment and genetic predisposition. METHODS:At baseline in 1975 same-sex twin pairs born in Finland before 1958 were sent ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1875-9
更新日期:2010-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Endothelial glycocalyx perturbation contributes to increased vascular permeability. In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties. METHODS:Male par...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1910-x
更新日期:2010-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. METHODS:Control and streptozotocin diabetic mice,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1837-2
更新日期:2010-11-01 00:00:00
abstract::Significant progress has been made in recent years in the characterisation of the signal pathways of beta cell dysfunction and death in the pathogenesis of type 2 diabetes. Glucolipotoxicity acts as an exogenous factor whereas oxidative stress and endoplasmic reticulum stress may result from the processes of signal re...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1839-0
更新日期:2010-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:A high prevalence of diabetes contributes to excess CHD in Indian Asians, but the underlying mechanisms are unclear. Heart rate, heart rate variability (HRV) and baroreflex sensitivity (BRS) are measures of cardiac autonomic function that are disturbed by hyperglycaemia and predict CHD. We compared thes...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1818-5
更新日期:2010-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Experimental studies have suggested that apoptosis is involved in diabetic embryopathy through oxidative stress. However, the precise mechanism of diabetic embryopathy is not yet clear. Thioredoxin (TRX) is a small, ubiquitous, multifunctional protein, which has recently been shown to protect cells from...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1784-y
更新日期:2010-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The glomerular endothelial layer is coated by the endothelial surface layer (ESL), which is suggested to play a role in regulation of the permselectivity of macromolecules. Production of heparanase, a degrading enzyme of the ESL, is induced by reactive oxygen species (ROS). We hypothesised that oxidativ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1810-0
更新日期:2010-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepat...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1721-0
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We assessed secular trends of cardiovascular outcomes following first diagnosis of myocardial infarction (MI) or diabetes in an unselected population. METHODS:All Danish residents aged > or = 30 years without prior diabetes or MI were identified by individual-level linkage of nationwide registers. Indi...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1783-z
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring. METHODS:The research was carried out within the Diabetes Prediction and Prevention...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1734-8
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Delivery of the gene for human vascular endothelial growth factor (VEGF, also known as VEGFA) to both the transplanted islets and the surrounding tissue may promote islet revascularisation and survival. We previously showed the effective delivery of VEGF gene to rat myocardium by an ultrasound-mediated ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1745-5
更新日期:2010-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Non-invasive imaging of the pancreatic beta cell mass (BCM) requires the identification of novel and specific beta cell biomarkers. We have developed a systems biology approach to the identification of promising beta cell markers. METHODS:We followed a functional genomics strategy based on massive para...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1714-z
更新日期:2010-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:A heavily polluted area of Eastern Slovakia was targeted by the PCBRISK cross-sectional survey to search for possible links between environmental pollution and both prediabetes and diabetes. METHODS:Associations of serum levels of five persistent organic pollutants (POPs), namely polychlorinated biphen...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-010-1683-2
更新日期:2010-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT(2)R) may modulate key processes linked to atherosclerosis. The aim of this study was to...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1619-x
更新日期:2010-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We analysed whether the prognosis of a first acute coronary syndrome (ACS) in patients treated for type 2 diabetes has improved. We also compared the trends in patients with and without diabetes. METHODS:We used national registers to identify all patients with clinically known type 2 diabetes in Finlan...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1606-2
更新日期:2010-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1618-y
更新日期:2010-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of the study was to analyse how strongly commuting and leisure-time physical activity affect progression to diabetes and to study whether this relationship is different in individuals with isolated impaired fasting glucose (i-IFG) and isolated impaired glucose tolerance (i-IGT). METHODS:We stud...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1587-1
更新日期:2010-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The rs1990760 polymorphism (Ala946Thr) of interferon induced with helicase C domain 1 (IFIH1) has been proposed to associate with type 1 diabetes. In this study, association between IFIH1 Ala946Thr and type 1 diabetes was investigated in two distinct white populations, the Hungarians and Finns. METHODS...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1561-y
更新日期:2010-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:The effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of aliskiren, a direct renin inhibitor, on cardiovascular injuries, glucose intolerance and pancreatic injury in a mouse model of type 2 diabetes. METHODS:Groups of db/db mice, w...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1575-5
更新日期:2010-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:A shift towards younger age at onset of diabetes in susceptible people has been suggested as a possible explanation for the increasing temporal trend in incidence of type 1 diabetes. We aimed to test this hypothesis by assessing trends in incidence rates in the period 1984-2004 in children and young adu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1538-x
更新日期:2009-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:We hypothesised that non-obese diabetic mice (NOD) mice have an autoimmune-mediated loss of islet sympathetic nerves and an impairment of sympathetically mediated glucagon responses. We aimed: (1) to determine whether diabetic NOD mice have an early impairment of the glucagon response to insulin-induced...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1494-5
更新日期:2009-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Advances in type 2 diabetes genetics have raised hopes that genetic testing will improve disease prediction, prevention and treatment. Little is known about current physician and patient views regarding type 2 diabetes genetic testing. We hypothesised that physician and patient views would differ regard...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1512-7
更新日期:2009-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:There has been much focus on the potential role of mitochondria in the aetiology of type 2 diabetes and the metabolic syndrome, and many case-control mitochondrial association studies have been undertaken for these conditions. We tested for a potential association between common mitochondrial variants a...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1510-9
更新日期:2009-11-01 00:00:00
abstract::Chronic diseases arising from obesity will continue to escalate over coming decades. Current approaches to combating obesity include lifestyle measures, surgical interventions and drugs that target weight reduction or the metabolic consequences of obesity. Lifestyle measures including physical activity are usually the...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1420-x
更新日期:2009-10-01 00:00:00
abstract::People with type 2 diabetes have an increased risk of cardiovascular disease (CVD). Multivariate cardiovascular risk scores have been used in many countries to identify individuals who are at high risk of CVD. These risk scores include those originally developed in individuals with diabetes and those developed in a ge...
journal_title:Diabetologia
pub_type: 杂志文章,评审
doi:10.1007/s00125-009-1454-0
更新日期:2009-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:This long-term study was designed to further characterise the retinal safety profile of insulin glargine and human neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes mellitus. METHODS:An open-label, 5 year, randomised (1:1), multicentre, stratified, parallel-group study conducted...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-009-1415-7
更新日期:2009-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased oxidative-nitrosative stress, poly(ADP-ribose) polymerase (PARP) activation and subsequent cellular damage play important roles in the complications of both diabetes mellitus and pregnancy. Our aim was to investigate nitrative stress and PARP activity levels during normal and gestational diabe...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1435-3
更新日期:2009-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:One major objective of the St Vincent Declaration was to reduce the excess risk of myocardial infarction in patients with diabetes mellitus. We estimated the trend of the incidence and relative risk of myocardial infarction in the diabetic and non-diabetic populations in southern Germany from 1985 to 20...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1434-4
更新日期:2009-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:In the light of a report suggesting that insulin glargine may increase cancer occurrence, the EASD asked us to perform this study. METHODS:We followed 114,841 individuals who had a prescription dispensed for insulin between 1 July and 31 December 2005. From 1 January 2006 to 31 December 2007, we noted ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1444-2
更新日期:2009-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study sought to identify genes and regions in the human genome that are associated with the acute insulin response to glucose (AIRg), an important predictor of type 2 diabetes, in Hispanic-American participants from the Insulin Resistance Atherosclerosis Family Study (IRAS FS). METHODS:A two-stage...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1373-0
更新日期:2009-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recent genome-wide association studies in East Asian populations reported that single nucleotide polymorphisms (SNPs) in KCNQ1 are associated with type 2 diabetes. The aim of this study was to validate this finding in a Chinese population. METHODS:We genotyped four SNPs, rs2074196, rs2237892, rs2237895...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1335-6
更新日期:2009-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Brain-derived neurotrophic factor (BDNF) is produced in skeletal muscle, but its functional significance is unknown. We aimed to determine the signalling processes and metabolic actions of BDNF. METHODS:We first examined whether exercise induced BDNF expression in humans. Next, C2C12 skeletal muscle ce...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1364-1
更新日期:2009-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Rosiglitazone, an insulin sensitiser, not only improves insulin sensitivity but also enhances insulin secretory capacity by ameliorating gluco- and lipotoxicity in beta cells. Rosiglitazone can stimulate insulin secretion at basal and high glucose levels via a phosphatidylinositol 3-kinase (PI3K)-depend...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1337-4
更新日期:2009-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:The UK Prospective Diabetes Study (UKPDS) risk engine has become a standard for cardiovascular risk assessment in type 2 diabetes mellitus. Skin autofluorescence was recently introduced as an alternative tool for cardiovascular risk assessment in diabetes. We investigated the prognostic value of skin au...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1308-9
更新日期:2009-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and adherence to dietary guidelines differ between adults with and without type 1 diabetes, and the...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1280-4
更新日期:2009-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glomerular hyperfiltration is a well-established phenomenon occurring early in some patients with type 1 diabetes. However, there is no consistent answer regarding whether hyperfiltration predicts later development of nephropathy. We performed a systematic review and meta-analysis of observational studi...
journal_title:Diabetologia
pub_type: 杂志文章,meta分析
doi:10.1007/s00125-009-1268-0
更新日期:2009-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The WFS1 gene encodes an endoplasmic reticulum (ER) membrane-embedded protein called Wolfram syndrome 1 protein, homozygous mutations of which cause selective beta cell loss in humans. The function(s) of this protein and the mechanism by which the mutations of this gene cause beta cell death are still n...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-009-1270-6
更新日期:2009-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Single nucleotide polymorphisms (SNPs) in G6PC2 have been reported to be associated with fasting plasma glucose level in several populations of European descent. However, whether G6PC2 variants have a similar effect in other ethnic groups is unknown. The aim of this study was to investigate the effect o...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1241-3
更新日期:2009-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Simultaneous kidney-pancreas transplantation is an established treatment for patients with type 1 diabetes and end-stage renal failure, even though restored beta cell function may become affected by recurrent islet autoimmunity or graft rejection. We characterised infiltrating lymphocytes isolated from ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1237-z
更新日期:2009-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to examine the effects of childhood BMI growth dynamics on the risk of developing young adult-onset type 1 and type 2 diabetes. METHODS:Finnish national healthcare registers were used to identify individuals with diabetes diagnosed between 1992 and 1996 at 15-39 years of age. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-008-1244-0
更新日期:2009-03-01 00:00:00